Emblica officinalis supplement health benefits, dosage. Phytochemistry, pharmacology and medicinal properties of. Even exposure to low levels of extract from these berries may be enough to impair tumor progression at early stages. Paclitaxel, one of most commonlyused chemotherapeutic agents, was used as a positive control. This medicinal plant is also reported to have anticancer, anti hivreverse transcriptase, antidiabetic. The fruits, which are of both dietary and medicinal use, are shown to possess myriad medicinal benefits and to.
It should be noted that there is concern regarding. Emblica officinalis, bioactive compounds, therapeutic value, pharmacological activity, ethnomedicine introduction or indian gooseberry is broached as wonder plant or as divine medicine. Assessment of therapeutic potential of phyllanthus emblica. The present study was carried out to assess quantitatively, the in vitro antibacterial activity of aqueous, ethanolic and acetone extracts of fruits of emblica officinalis. Both undoped and ti ion doped cerium oxide nanoparticles possess photocatalytic activity, while the latter shows enhanced degradation efficiency percentage and can be used as effective photocatalyst. Review article anticancer properties of phyllanthus emblica indian. Dweck fls frsh frsc, dweck data david mitchell, chesham chemicals ltd introduction the world craves new ideas and looks to the far east and asia for inspiration and innovation. Possible involvement of monoaminergic neurotransmission in. O was found to be cytotoxic to l 929 cells in culture in a dose dependent manner.
Emblica officinalis amla is an ayurvedic herb which has all parts, including the fruits, used for preventative and therapeutic purposes. Phyllanthus emblica, medicinal herb, anticarcinogenic, antitumor activity. Corilagin, a tannin, was mostly focused on the antioxidant activity 25, 26, whereas the antitumor activity was not much accounted for. Anticancer properties of phyllanthus emblica indian. In the present study, immunomodulatory and anticancer activities of phenolic compounds isolated from emblica fruit on mouse splenocytes, human breast cancer cells mcf7 and human embryonic lung fibroblast helf were investigated, respectively.
Antioxidant activity of active tannoid principles of. An overview article pdf available in international research journal of pharmacy 22. Emblica officinalis, commonly known as amla, is an important medicinal plant of india. Calcutta, boepartments of ophthalmology and pharmacologl. Emblica officinalis, commonly known as the indian gooseberry, is an important medicinal plant in the traditional indian system of ayurvedic medicine. Invitro antihelicobacter pylori activity of emblica officinalis 12 3a. Correlation between scavenging property and antioxidant. It strengthen the lungs, helping to fight chronic lung problems as well as upper respiratory infections. The aim of this study was to investigate the beneficial effect of the hydroalcoholic extract of the fruits of emblica officinalis eo on. Phyllanthus emblica euphorbiaceae possesses a vast ethnomedical history and represents a phytochemical reservoir of heuristic medicinal value. An overview of adaptogens david winston, ahg, 2004 the idea of using tonic remedies to restore balance and health in a person is an ancient idea.
Phyllanthus emblica, medicinal herb, anticarcinogenic, antitumor activity, chemoprevention. Normally herbal products are free from side effectsadverse effects and they are low cost medicines, which will be beneficial for human being. Department of biotechnology, valliammal college for women. It appears to be most used for regulating glucose metabolism and cardiac health, and may also be neuroprotective. Amla emblica officinalis gaertn, a wonder berry in the. Gopalakrishna, amla emblica officinalis extract is effective in preventing high fructose dietinduced insulin resistance and atherogenic dyslipidemic profile in ovariectomized female albino rats, menopause. Antioxidant, immunomodulatory and anticancer activities of. The free radicalscavenging activity of plants extract. Department of surgery priyamvada birla cancer research institute satna, m. To date, there is substantial evidence that these extracts contain small molecules with both cancerpreventative and antitumor activity.
Evaluation of antipyretic and analgesic activity of. Materials and methods plant material the fruits of e. Antioxidant, immunomodulatory and anticancer activities of emblica officinalis. Rats were examined for the antioxidant properties of amla extracts and its effect on the oxidative stress in streptozotocin induced diabetes was also reported. Its fruits have potent antioxidant activity due to the presence of tannoids, tannins, vitamin c and flavonoids.
Antitumour effects of phyllanthus emblica l induction of. Morphological variation in the indian gooseberries. In this study, our research suggested that corilagin has better antitumor activity, broadspectrum antitumor activity, and less toxicity to normal cells and can promote the antitumor activity of cddp. Vitamin c in emblica officinalis accounts for approximately 4570% of the antioxidant activity18. Emblica officinalis gaertn phyllanthus emblica, linn family euphorbiaceae is a medicinal plant. Essentials perspectives for emblica officinalis international journal of pharmaceutical and chemical sciences. Green synthesis of undoped and titanium ion doped cerium. Pharmacological screening of ethanolic extracts of emblica.
The present communication deals with the gcms analysis of phytocomponents in the methanolic extract. Emblica officinalis is a deciduous tree prevalent in some parts of asia. The antitumor effect of phyllanthus species was first. Pdf antioxidant, immunomodulatory and anticancer activities of. Phyllanthus emblica, also known as emblic, emblic myrobalan, myrobalan, indian gooseberry, malacca tree, or amla from sanskrit amalaki is a deciduous tree of the family phyllanthaceae. It is a wellknown fact that all parts of amla are useful in the treatment of various diseases. Third, phyllanthus emblica extracts have antiinflammatory activities that might prevent inflammation related cancers. The liver of female wistar rats treated with lead acetate at different concentrations showed.
Antioxidant and antitumor activity of phyllanthus emblica in colon. Protective effect of emblica officinalis ethanolic extract. Pdf emblica officinalis amla is traditionally used for several diseases, and it is believed to increase the defense against diseases. Antioxidant and antitumor activity of phyllanthus emblica in colon cancer cell lines.
Comparative antibacterial activity of fruit extracts of. Pdf anticancer properties of phyllanthus emblica indian. Comparative antibacterial activity of fruit extracts of emblica. Morphological variation in the indian gooseberries phyllanthus emblica and phyllanthus indofischeri and the chloroplast trnl uaa intron as candidate gene for their identification volume 8 issue 3 n. Emblica officinalis with its nutritional value, biochemical constituents, traditional uses, medicinal value of amla and its use as a household remedy. Download citation antitumor activity of emblica officinalis aqueous. The fruits, which are of both dietary and medicinal use, are shown to possess myriad medicinal benefits and to possess antiaging effects. The journal of the north american menopause society, 19.
In this investigation, we report the antidiarrheal effect of the methanol extract of the fruit of e. Amla fruit is sour, sweet and astringent in taste, and cooling in action. Phyllanthus emblica an overview sciencedirect topics. Green synthesis, ceria nanoparticles, emblica officinalis, photocatalytic activity. Aqueous extract of emblica officinalis was found to be cytotoxic to l929 cells, and further results suggest cell cycle regulation as a result of antitumor activity of e. Various parts of the plant are used to treat a range of diseases, but the most important is the fruit. Emblica officinalis amla are widely used in the indian system of medicine and believed to increase defense against diseases. The results suggest that antitumor activity of emblica officinalis extract may partially be due to its interaction with cell cycle regulation 7. Quality assessment and evaluation of invitro antioxidant. Anticancer properties of phyllanthus emblica indian gooseberry. Emblica officinalis is reported to have antitumor activity 42, 45, 54 together with beneficial effects in gynecological, hepatic, respiratory and skin 43, 44 disorders. All parts of the tree, especially the fruit, are commonly used in traditional medicine for various ailments including diarrhea, jaundice, headaches, inflammation, and as a tonic. A pharmacological perspective global research online.
Ethanolic extract of emblica officinalis eo fruit extract was evaluated for protection against genotoxicity induced by the rodent carcinogen, 7,12dimethylbenzaanthracene dmba. A correlation of aqueous and ethanolic extract of emblica fruit along with different known standards for its antioxidative properties was made by performing assays. Evaluation of antidiarrheal potential of emblica officinalis. It is a rasayana tonic that promotes longevity, and is especially good for the heart. Antitumor activity of emblica officinalis researchgate. The word and concept of an adaptogen is a relatively new way of describing a type of remedy commonly. Phytochemistry, pharmacological activities and traditional uses of. Amla, emblica officinalis, vitamin c, ayurvedic medicines, hair growth tonic. Emblica officinalis is commonly known as indian gooseberry. All parts of the plant are used for medicinal purposes, especially the.
Research article cytoinhibitory potential of phyllanthus. Antimutagenic and wound healing activity of emblica officinalis extract in swiss albino mice r. Srikumar4 1department of microbiology, sri lakshmi narayana institute of medical sciences and hospital, osudu, agaram village, villianur commune, kudupakkam post, puducherry605. It is also one of the constituents of a popular ayurvedic formulation, triphala. Invitro antihelicobacter pylori activity of emblica. The antioxidant function of phyllanthus emblica can account for some of the anticancer activity, but clearly other mechanisms are equally. Finally, as we will describe below, phyllanthus emblica harbors potent antitumor activity 21, 22. Possible involvement of monoaminergic neurotransmission in antidepressant. Herein, we provide a brief overview of the evidence supporting anticancer activity of indian gooseberry extracts, suggest possible mechanisms for these actions.
Triphala triphala is a botanical preparation comprised of equal parts of three herbal fruits. Antimutagenic and wound healing activity of emblica. The fruit is used either alone or in combination with other plants to treat many. However, the biological activity of emblica officinalis extracts of possible interest for treatment of arthritis and osteoporosis have not yet been reported. All parts of the plant are used for medicinal purposes, especially. Immunomodulatory and anticancer activities of phenolics. Emblica officinalis memorial sloan kettering cancer center. It is an indispensable part of the ayurvedic and unani system with amazing remedial qualities. Research department jawahar lal nehru cancer hospital and research centre idgah hills, bhopal, m.
This article discuses and summarizes important medicinal values ofemblica officinalis eo. Induction of apoptosis of human primary osteoclasts. Gcms analysis of phytocomponents in the methanolic. Read immunomodulatory and anticancer activities of phenolics from emblica fruit phyllanthus emblica l. Oral administration of eo fruit extract in various concentrations 100, 250, 500mgkg b. Its cardiotonic activity is more like the actions of adrenalin. Emblica officinalis to study the different phytochemical present in this plant and their role in the treatment of various ailments. Harada terminalia chebula, black myrobalan, the buddhas chosen herb, amla emblica officinalisor indian gooseberry, and bihara terminalia bellerica. Emblica officinalis, antibacterial assay, well diffusion, fruit extract, s. It shows expectorant activity, but its isolated constituents like gallic acid, tannins, ascorbic acid, phyllemblin do not show expectorant activity. Screening of siddha medicinal plants for anti cancer. Assessment of therapeutic potential of phyllanthus emblica amla.
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